The prognostic value of adipose tissue fatty acids for incident cardiovascular disease: results from 3944 subjects in the Scottish Heart Health Extended Cohort Study
Identifieur interne : 006619 ( Main/Exploration ); précédent : 006618; suivant : 006620The prognostic value of adipose tissue fatty acids for incident cardiovascular disease: results from 3944 subjects in the Scottish Heart Health Extended Cohort Study
Auteurs : Mark Woodward [Royaume-Uni, États-Unis, Australie] ; Hugh Tunstall-Pedoe [Royaume-Uni] ; G. David Batty [Royaume-Uni] ; Roger Tavendale [Royaume-Uni] ; Frank B. Hu [États-Unis] ; Sebastien Czernichow [France]Source :
- European heart journal [ 0195-668X ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
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Abstract
Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods Adipose tissue was taken from 3944 participants, predominantly aged 40-59 years, in Scotland, 1984-87. Per-and results centages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95% confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4%, respectively, with only the latter being significant at the 5% level. Conclusions A diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.
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Affiliations:
- Australie, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Massachusetts, Nouvelle-Galles du Sud, Île-de-France
- Bobigny, Boston, Londres, Sydney
- University College de Londres, Université de Sydney
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Box M201, Missenden Road</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Tunstall Pedoe, Hugh" sort="Tunstall Pedoe, Hugh" uniqKey="Tunstall Pedoe H" first="Hugh" last="Tunstall-Pedoe">Hugh Tunstall-Pedoe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Epidemiology, Institute of Cardiovascular Research, University of Dundee</s1><s2>Dundee</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Medical Research Council Social & Public Health Sciences Unit</s1><s2>Glasgow</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Medical Research Council Social & Public Health Sciences Unit</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Epidemiology and Public Health, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Tavendale, Roger" sort="Tavendale, Roger" uniqKey="Tavendale R" first="Roger" last="Tavendale">Roger Tavendale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Epidemiology, Institute of Cardiovascular Research, University of Dundee</s1><s2>Dundee</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Nutrition, Harvard School of Public Health</s1><s2>Boston</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Epidemiology, Harvard School of Public Health</s1><s2>Boston</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Département de Sante Publique, Hôpital Avicenne (AP-HP) & Universite Paris 13</s1><s2>Bobigny</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Unité de Recherche en Epidemiologie Nutritionnelle (UMR INSERMU557, INRA, CNAM, UP13), CRNH-IdF</s1><s2>Bobigny</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose tissue</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Circulatory system</term><term>Cohort study</term><term>Fatty acids</term><term>Health</term><term>Heart</term><term>Human</term><term>Incidence</term><term>Myocardial infarction</term><term>Predictive value</term><term>Result</term><term>Risk</term><term>Risk factor</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infarctus du myocarde</term><term>Accident cérébrovasculaire</term><term>Valeur prédictive</term><term>Tissu adipeux</term><term>Acide gras</term><term>Incidence</term><term>Pathologie de l'appareil circulatoire</term><term>Résultat</term><term>Homme</term><term>Coeur</term><term>Santé</term><term>Etude cohorte</term><term>Facteur risque</term><term>Risque</term><term>Appareil circulatoire</term><term>Cardiologie</term><term>Maladie cardiovasculaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims Dietary fats are routinely considered key determinants of cardiovascular risk, yet the scientific basis of this association has never been demonstrated using objective measures of fat intakes in a large prospective study in a general population. Methods Adipose tissue was taken from 3944 participants, predominantly aged 40-59 years, in Scotland, 1984-87. Per-and results centages of individual fatty acids were measured using gas chromatography. Over a median of 19.5 years, 870 incident cardiovascular disease (CVD) events occurred. Hazard ratios (HRs) were obtained from Cox models and the additional prognostic value, accounting for variables in the Framingham and ASSIGN CVD risk scores, were assessed using discrimination indices. Adjusting for age, sex, total and HDL-cholesterol, systolic blood pressure, smoking, hypertensive medication use, diabetes, socio-economic status and family history, the percentage of monounsaturated adipose tissue fatty acids had a positive log-linear relationship with incident CVD: the HR comparing risk between the fourth and first quartiles was 1.29 (95% confidence interval: 1.05, 1.59). n-3 polyunsaturated fat showed the reverse trend, the corresponding result being 0.77 (0.63, 0.94). These two composite variables improved the classification of incident CVD events by 1.0 and 6.4%, respectively, with only the latter being significant at the 5% level. Conclusions A diet which is proportionately rich in polyunsaturated fat, as opposed to other fats, is expected to decrease the risk of CVD independently of the effects of common CVD risk factors, including social deprivation. Taking account of such diets improves the classification of future CVD events.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Boston</li><li>Londres</li><li>Sydney</li></settlement><orgName><li>University College de Londres</li><li>Université de Sydney</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></noRegion><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G. David" last="Batty">G. David Batty</name><name sortKey="Tavendale, Roger" sort="Tavendale, Roger" uniqKey="Tavendale R" first="Roger" last="Tavendale">Roger Tavendale</name><name sortKey="Tunstall Pedoe, Hugh" sort="Tunstall Pedoe, Hugh" uniqKey="Tunstall Pedoe H" first="Hugh" last="Tunstall-Pedoe">Hugh Tunstall-Pedoe</name></country><country name="États-Unis"><noRegion><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></noRegion><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name><name sortKey="Hu, Frank B" sort="Hu, Frank B" uniqKey="Hu F" first="Frank B." last="Hu">Frank B. Hu</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name></region><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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